NDLI: Influence of CrgA on Assembly of the Cell Division Protein FtsZ during Development of Streptomyces coelicolor

Content Provider	PubMed Central
Author	Sol, Ricardo Del Mullins, Jonathan G. L. Grantcharova, Nina Klas, Flärdh Dyson, Paul
Copyright Year	2006
Abstract	The product of the crgA gene of Streptomyces coelicolor represents a novel family of small proteins. A single orthologous gene is located close to the origin of replication of all fully sequenced actinomycete genomes and borders a conserved gene cluster implicated in cell growth and division. In S. coelicolor, CrgA is important for coordinating growth and cell division in sporogenic hyphae. In this study, we demonstrate that CrgA is an integral membrane protein whose peak expression is coordinated with the onset of development of aerial hyphae. The protein localizes to discrete foci away from growing hyphal tips. Upon overexpression, CrgA localizes to apical syncytial cells of aerial hyphae and inhibits the formation of productive cytokinetic rings of the bacterial tubulin homolog FtsZ, leading to proteolytic turnover of this major cell division determinant. In the absence of known prokaryotic cell division inhibitors in actinomycetes, CrgA may have an important conserved function influencing Z-ring formation in these bacteria.
Related Links	http://dx.doi.org/10.1128/JB.188.4.1540-1550.2006
Starting Page	1540
File Format	PDF
ISSN	10985530
e-ISSN	10985530
Journal	Journal of Bacteriology
Issue Number	4
Volume Number	188
Language	English
Publisher	American Society for Microbiology
Publisher Date	2006-02-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Microbiology

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Dynamics of FtsZ Assembly during Sporulation in Streptomyces coelicolor A3(2)

FtsW Is a Dispensable Cell Division Protein Required for Z-Ring Stabilization during Sporulation Septation in Streptomyces coelicolor ▿ †

Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces.

Novel Genes That Influence Development in Streptomyces coelicolor

Concentration and Assembly of the Division Ring Proteins FtsZ, FtsA, and ZipA during the Escherichia coli Cell Cycle

Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor

Assembly of an FtsZ Mutant Deficient in GTPase Activity Has Implications for FtsZ Assembly and the Role of the Z Ring in Cell Division

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The Antibacterial Cell Division Inhibitor PC190723 Is an FtsZ Polymer-stabilizing Agent That Induces Filament Assembly and Condensation

Influence of CrgA on Assembly of the Cell Division Protein FtsZ during Development of Streptomyces coelicolor

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Dynamics of FtsZ Assembly during Sporulation in Streptomyces coelicolor A3(2)

FtsW Is a Dispensable Cell Division Protein Required for Z-Ring Stabilization during Sporulation Septation in Streptomyces coelicolor ▿ †

Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces.

Novel Genes That Influence Development in Streptomyces coelicolor

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