NDLI: An exosome-like complex in Sulfolobus solfataricus

Content Provider	PubMed Central
Author	Elena, Evguenieva-hackenberg Walter, Pamela Hochleitner, Elisabeth Friedrich, Lottspeich Klug, Gabriele
Copyright Year	2003
Abstract	We present the first experimental evidence for the existence of an exosome-like protein complex in Archaea. In Eukarya, the exosome is essential for many pathways of RNA processing and degradation. Co-immunoprecipitation with antibodies directed against the previously predicted Sulfolobus solfataricus orthologue of the exosome subunit ribosomal-RNA-processing protein 41 (Rrp41) led to the purification of a 250-kDa protein complex from S. solfataricus. Approximately half of the complex cosediments with ribosomal subunits. It comprises four previously predicted orthologues of the core exosome subunits from yeast (Rrp41, Rrp42, Rrp4 and Csl4 (cep1 synthetic lethality 4; an RNA-binding protein and exosome subunit)), whereas other predicted subunits were not found. Surprisingly, the archaeal homologue of the bacterial DNA primase DnaG was tightly associated with the complex. This suggests an RNA-related function for the archaeal DnaG-like proteins. Comparison of experimental data from different organisms shows that the minimal core of the exosome consists of at least one phosphate-dependent ribonuclease PH homologue, and of Rrp4 and Csl4. Such a protein complex was probably present in the last common ancestor of Archaea and Eukarya.
Related Links	http://dx.doi.org/10.1038/sj.embor.embor929
Ending Page	893
Page Count	5
Starting Page	889
File Format	PDF
ISSN	1469221X
e-ISSN	14693178
Journal	EMBO Reports
Issue Number	9
Volume Number	4
Language	English
Publisher Date	2003-08-01
Access Restriction	Open
Subject Keyword	Genetics Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology

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