NDLI: A model for the lipid pretransition: coupling of ripple formation with the chain-melting transition.

Content Provider	PubMed Central
Author	Heimburg, T.
Abstract	Below the thermotropic chain-melting transition, lipid membrane c(P) traces display a transition of low enthalpy called the lipid pretransition. It is linked to the formation of periodic membrane ripples. In the literature, these two transitions are usually regarded as independent events. Here, we present a model that is based on the assumption that both pretransition and main transition are caused by the same physical effect, namely chain melting. The splitting of the melting process into two peaks is found to be a consequence of the coupling of structural changes and chain-melting events. On the basis of this concept, we performed Monte Carlo simulations using two coupled monolayer lattices. In this calculation, ripples are considered to be one-dimensional defects of fluid lipid molecules. Because lipids change their area by approximately 24% upon melting, line defects are the only ones that are topologically possible in a triangular lattice. The formation of a fluid line defect on one monolayer leads to a local bending of the membrane. Geometric constraints result in the formation of periodic patterns of gel and fluid domains. This model, for the first time, is able to predict heat capacity profiles, which are comparable to the experimental c(P) traces that we obtained using calorimetry. The basic assumptions are in agreement with a large number of experimental observations.
Related Links	http://dx.doi.org/10.1016/s0006-3495(00)76673-2
Ending Page	1165
Page Count	12
Starting Page	1154
File Format	PDF
ISSN	00063495
e-ISSN	15420086
Journal	Biophysical Journal
Issue Number	3
Volume Number	78
Language	English
Publisher Date	2000-03-01
Access Restriction	Open
Subject Keyword	Biophysics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biophysics

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