NDLI: Mutagenesis and repair by low doses of α radiation in mammalian cells

Content Provider	PubMed Central
Author	Puck, Theodore T. Johnson, Robert Webb, Patricia Cui, Helen Valdez, Joseph G. Crissman, Harry
Copyright Year	2002
Abstract	Low doses of α radiation in basements have been causally implicated in lung cancer. Previous studies have concentrated on high dose effects, for which no significant repair was found. In the present study, the methodology for measuring mutation by quantitating mitotic breaks and gaps was found to be applicable to G2-phase Chinese hamster ovary cells irradiated with 10–50 cGy of α radiation. The mutation yield in such cells closely resembles that of γ irradiation. Caffeine, which inhibits repair, produces the same straight line increase of α and γ mutation yields plotted against the dose. In the absence of caffeine, the repair of α radiation lesions is almost twice as great as for γ radiation. Mitotic index changes substantiate these interpretations. It is proposed that the higher ion density associated with α radiation may result in fewer lesions being missed by the repair processes. The quantitation of chromosomal lesions for G2 cells exposed to low doses of α radiation, γ radiation, or chemical mutagens in the presence and absence of caffeine is a rapid and reproducible methodology. Protection from mutational disease in a fashion similar to the use of sanitation for infectious disease appears practical.
Related Links	http://dx.doi.org/10.1073/pnas.152433699
Ending Page	12223
Page Count	4
Starting Page	12220
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	19
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-09-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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