NDLI: On the role of calcium in the electrical responses of cockroach salivary gland cells to dopamine.

Content Provider	PubMed Central
Author	Ginsborg, B. L. Mitchell, M. R. House, C. R.
Abstract	1. The calcium dependence of the intracellularly recorded hyperpolarizing responses of salivary gland acinar cells of Nauphoeta cinerea (Olivier) to ionophoretically applied dopamine has been examined. The results of withdrawing calcium from the bathing solution were essentially the same whether or not other divalent cations were present. The effects of calcium withdrawal were rapidly reversed on replacement of calcium. 2. Small responses to dopamine were reduced or abolished by calcium withdrawal but could be restored by an increase in the amount of ejected dopamine. Calcium withdrawal did not have any consistent effect on the input resistance: a reduction in input resistance is therefore not the main cause of the reduction in the amplitude of the responses to dopamine. 3. In very low calcium solutions responses elicited by repeated prolonged dopamine applications progressively declined. 4. It is suggested that the hyperpolarizing responses to dopamine depend on an influx of calcium into the cytosol from a store which can be replenished only from the exterior.
Ending Page	335
Starting Page	325
File Format	PDF
ISSN	14697793
e-ISSN	14697793
Journal	The Journal of Physiology
Volume Number	303
Language	English
Publisher Date	1980-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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On the role of calcium in the electrical responses of cockroach salivary gland cells to dopamine.