NDLI: Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

Content Provider	PubMed Central
Author	He, Wei Li, Allen G. Wang, Dongyan Han, Shuhua Zheng, Biao Goumans, Marie-josé Dijke, Peter Ten Wang, Xiao-jing
Copyright Year	2002
Abstract	Biochemical studies have shown that Smad7 blocks signal transduction of transforming growth factor β (TGFβ); however, its in vivo functions are largely unknown. To determine the functions of Smad7, we have expressed Smad7 in transgenic mice, utilizing a keratin K5 promoter (K5.Smad7). K5.Smad7 mice exhibited pathological changes in multiple tissues and died within 10 days after birth. These mice were born with open eyelids and corneal defects, significantly delayed and aberrant hair follicle morphogenesis, and hyperproliferation in the epidermis and other stratified epithelia. Furthermore, K5.Smad7 mice developed severe thymic atrophy and massive thymocyte death, suggesting that Smad signaling in thymic epithelia is essential for thymocyte survival. Interestingly, in addition to a reduction in Smad phosphorylation, the protein levels of the receptors for TGFβ, activin and bone morphogenetic protein were significantly decreased in the affected tissues of K5.Smad7 mice. Our study provides evidence that Smad7 is a potent in vivo inhibitor for signal transduction of the TGFβ superfamily during development and maintenance of homeostasis of multiple epithelial tissues.
Related Links	http://dx.doi.org/10.1093/emboj/21.11.2580
Ending Page	2590
Page Count	11
Starting Page	2580
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	11
Volume Number	21
Language	English
Publisher	Oxford University Press
Publisher Date	2002-06-03
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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