NDLI: The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis

Content Provider	PubMed Central
Author	Maclusky, Neil J. Tibor, Hajszan Csaba, Leranth
Abstract	Bisphenol A (BPA) is an estrogenic chemical that is widely used in the manufacture of plastics and epoxy resins. Because BPA leaches out of plastic food and drink containers, as well as the BPA-containing plastics used in dental prostheses and sealants, considerable potential exists for human exposure to this compound. In this article we show that treatment of ovariectomized rats with BPA dose-dependently inhibits the estrogen-induced formation of dendritic spine synapses on pyramidal neurons in the CA1 area of the hippocampus. Significant inhibitory effects of BPA were observed at a dose of only 40 μg/kg, below the current U.S. Environmental Protection Agency reference daily limit for human exposure. Because synaptic remodeling has been postulated to contribute to the rapid effects of estrogen on hippocampus-dependent memory, these data suggest that environmental BPA exposure may interfere with the development and expression of normal sex differences in cognitive function, via inhibition of estrogen-dependent hippocampal synapse formation. It may also exacerbate the impairment of hippocampal function observed during normal aging, as endogenous estrogen production declines.
Related Links	http://dx.doi.org/10.1289/ehp.7633
Ending Page	679
Page Count	5
Starting Page	675
File Format	PDF
ISSN	00916765
e-ISSN	15529924
Journal	Environmental Health Perspectives
Issue Number	6
Volume Number	113
Language	English
Publisher	National Institue of Environmental Health Sciences
Publisher Date	2005-02-01
Access Restriction	Open
Rights Holder	National Institue of Environmental Health Sciences
Subject Keyword	Public Health, Environmental and Occupational Health Health, Toxicology and Mutagenesis Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health

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