NDLI: Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells

Content Provider	PubMed Central
Author	Vitale, Nicolas Caumont, Anne-sophie Chasserot-golaz, Sylvette Du, Guangwei Wu, Si Sciorra, Vicki A. Morris, Andrew J. Frohman, Michael A. Bader, Marie-france
Copyright Year	2001
Abstract	Phospholipase D (PLD) has been proposed to mediate cytoskeletal remodeling and vesicular trafficking along the secretory pathway. We recently described the activation of an ADP ribosylation factor-regulated PLD at the plasma membrane of chromaffin cells undergoing secretagogue-stimulated exocytosis. We show here that the isoform involved is PLD1b, and, using a real-time assay for individual cells, that PLD activation and exocytosis are closely correlated. Moreover, overexpressed PLD1, but not PLD2, increases stimulated exocytosis in a phosphatidylinositol 4,5-bisphosphate-dependent manner, whereas catalytically inactive PLD1 inhibits it. These results provide the first direct evidence that PLD1 is an important component of the exocytotic machinery in neuroendocrine cells.
Related Links	http://dx.doi.org/10.1093/emboj/20.10.2424
Ending Page	2434
Page Count	11
Starting Page	2424
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	10
Volume Number	20
Language	English
Publisher	Oxford University Press
Publisher Date	2001-05-15
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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