NDLI: The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation

Content Provider	PubMed Central
Author	Yin, Zhan Haynie, Jennifer Yang, Xiaoming Han, Baoguang Kiatchoosakun, Songsak Restivo, Joseph Yuan, Saying Prabhakar, Nanduri R. Herrup, Karl Conlon, Ronald A. Hoit, Brian D. Watanabe, Michiko Yang, Yu-chung
Abstract	Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1α through its competitive binding with HIF-1α to CBP/p300. Disruption of the gene encoding Cited2 is embryonic lethal because of defects in the development of heart and neural tube. Morphological and Doppler echocardiographic analyses of Cited2−/− embryos reveal severe cardiovascular abnormalities, including pulmonic arterial stenosis and ventricular septal defects accompanied by high peak outflow velocities, features of the human congenital cardiac defect termed tetralogy of Fallot. The mRNA levels of several HIF-1α-responsive genes, such as vascular endothelial growth factor (VEGF), Glut1, and phosphoglycerate kinase 1, increased in the Cited2−/− hearts. The increase of VEGF levels is significant, because defects in the Cited2−/− embryos closely resemble the major defects observed in the VEGF transgenic embryos. Finally, compared with wild-type, cultured fibroblasts from Cited2−/− embryos demonstrate an enhanced expression of HIF-1α-responsive genes under hypoxic conditions. These observations suggest that functional loss of Cited2 is responsible for defects in heart and neural tube development, in part because of the modulation of HIF-1 transcriptional activities in the absence of Cited2. These findings demonstrate that Cited2 is an indispensable regulatory gene during prenatal development.
Related Links	http://dx.doi.org/10.1073/pnas.162371799
Ending Page	10493
Page Count	6
Starting Page	10488
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-08-06
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.

PACT is a negative regulator of p53 and essential for cell growth and embryonic development

Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes

CITED2 mediates the paradoxical responses of HIF-1α to proteasome inhibition

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α–dependent function

Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator

A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation

Structural basis for Hif-1α/CBP recognition in the cellularhypoxic response

Investigations of the Underlying Mechanisms of HIF-1α and CITED2 Binding to TAZ1

The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation

Similar Documents

The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.

PACT is a negative regulator of p53 and essential for cell growth and embryonic development

Deletion of HIF-1α partially rescues the abnormal hyaloid vascular system in Cited2 conditional knockout mouse eyes

CITED2 mediates the paradoxical responses of HIF-1α to proteasome inhibition

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α–dependent function

Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator

A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation

Structural basis for Hif-1α/CBP recognition in the cellularhypoxic response

Investigations of the Underlying Mechanisms of HIF-1α and CITED2 Binding to TAZ1

The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation