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| Content Provider | PubMed Central |
|---|---|
| Author | Izumiya, Hidemasa Mori, Kadumi Takayuki, Kurazono Yamaguchi, Masanori Higashide, Masato Konishi, Noriko Kai, Akemi Morita, Koji Terajima, Jun Watanabe, Haruo |
| Copyright Year | 2005 |
| Abstract | Strains of the multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium isolated in Japan were examined for high-level fluoroquinolone resistance. Since the first isolation in 2000 (described in reference 13), we have identified 12 human and 5 nonhuman isolates with high-level fluoroquinolone-resistance (ciprofloxacin MIC of 24 μg/ml or more). Most of these isolates shared some features including definitive phage type (DT12/193), resistance type (ACSSuTNCp; resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, tetracycline, nalidixic acid, and ciprofloxacin), and genotype on pulsed-field gel electrophoresis that were different from those of the MDR S. enterica Typhimurium DT104. Mutations in quinolone resistance-determining regions of gyrA and parC were also conserved in almost all of the isolates despite the absence of any apparent epidemiological relationships among cases. This suggests that a specific clonal group of the serovar Typhimurium with high levels of fluoroquinolone resistance is disseminating among animals and humans in Japan. |
| Related Links | http://dx.doi.org/10.1128/jcm.43.10.5074-5079.2005 |
| Ending Page | 5079 |
| Page Count | 6 |
| Starting Page | 5074 |
| File Format | |
| ISSN | 00951137 |
| e-ISSN | 1098660X |
| Journal | Journal of Clinical Microbiology |
| Issue Number | 10 |
| Volume Number | 43 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2005-10-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Microbiology (medical) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) |
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