NDLI: BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

Content Provider	PubMed Central
Author	Loukinov, Dmitri I. Pugacheva, Elena Sergei, Vatolin Pack, Svetlana D. Moon, Hanlim Chernukhin, Igor Mannan, Poonam Larsson, Erik Chandrasekhar, Kanduri Vostrov, Alexander A. Cui, Hengmi Niemitz, Emily L. Rasko, John E. J. Docquier, France M. Kistler, Malathi Breen, Joseph J. Zhuang, Zhengping Quitschke, Wolfgang W. Rainer, Renkawitz Klenova, Elena M. Feinberg, Andrew P. Ohlsson, Rolf Morse, Herbert C. Lobanenkov, Victor V.
Copyright Year	2002
Abstract	CTCF, a conserved, ubiquitous, and highly versatile 11-zinc-finger factor involved in various aspects of gene regulation, forms methylation-sensitive insulators that regulate X chromosome inactivation and expression of imprinted genes. We document here the existence of a paralogous gene with the same exons encoding the 11-zinc-finger domain as mammalian CTCF genes and thus the same DNA-binding potential, but with distinct amino and carboxy termini. We named this gene BORIS for Brother of the Regulator of Imprinted Sites. BORIS is present only in the testis, and expressed in a mutually exclusive manner with CTCF during male germ cell development. We show here that erasure of methylation marks during male germ-line development is associated with dramatic up-regulation of BORIS and down-regulation of CTCF expression. Because BORIS bears the same DNA-binding domain that CTCF employs for recognition of methylation marks in soma, BORIS is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line.
Related Links	http://dx.doi.org/10.1073/pnas.092123699
Ending Page	6811
Page Count	6
Starting Page	6806
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	99
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2002-05-14
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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