NDLI: Molecular dissection of hippocampal theta-burst pairing potentiation

Content Provider	PubMed Central
Author	Hoffman, D. A. Sprengel, R. Sakmann, B.
Copyright Year	2002
Abstract	Long-term potentiation (LTP) of synaptic efficacy in the hippocampus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsynaptic depolarization. Adult (P42) GluR-A−/− mice largely lack these forms of LTP. LTP in wt mice can also be induced by coincident pre- and postsynaptic action potentials, where an initial rapid component is expressed but a substantial fraction of the potentiation develops with a delayed time course. We report here that this stimulation protocol, delivered at theta frequency (5 Hz), induces LTP in GluR-A−/− mice in which the initial component is substantially reduced. The remaining GluR-A independent component differs from the initial component in that its expression develops over time after induction and its induction is differentially dependent on postsynaptic intracellular Ca2+ buffering. Thus, in adult mice, theta-burst pairing evokes two forms of synaptic potentiation that are induced simultaneously but whose expression levels vary inversely with time. The two components of synaptic potentiation could be relevant for different forms of information storage that are dependent on hippocampal synaptic transmission such as spatial reference and working memory.
Related Links	http://dx.doi.org/10.1073/pnas.092157999
Ending Page	7745
Page Count	6
Starting Page	7740
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	99
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2002-05-28
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular dissection of hippocampal theta-burst pairing potentiation

Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning

Genetic dissection of theta rhythm heterogeneity in mice

Relationship of Hippocampal Theta and Gamma Oscillations to Potentiation of Synaptic Transmission

Long-Term Potentiation by Theta-Burst Stimulation Using Extracellular Field Potential Recordings in Acute Hippocampal Slices.

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

Oscillatory brain states and learning: Impact of hippocampal theta-contingent training

Antiseizure Drugs Differentially Modulate Theta-Burst Induced Long-Term Potentiation in C57BL/6 Mice

Contribution of astrocytes to hippocampal long-term potentiation through release of d-serine

Molecular dissection of hippocampal theta-burst pairing potentiation

Similar Documents

Molecular dissection of hippocampal theta-burst pairing potentiation

Cerebellar theta oscillations are synchronized during hippocampal theta-contingent trace conditioning

Genetic dissection of theta rhythm heterogeneity in mice

Relationship of Hippocampal Theta and Gamma Oscillations to Potentiation of Synaptic Transmission

Long-Term Potentiation by Theta-Burst Stimulation Using Extracellular Field Potential Recordings in Acute Hippocampal Slices.

Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

Oscillatory brain states and learning: Impact of hippocampal theta-contingent training

Antiseizure Drugs Differentially Modulate Theta-Burst Induced Long-Term Potentiation in C57BL/6 Mice

Contribution of astrocytes to hippocampal long-term potentiation through release of d-serine

Molecular dissection of hippocampal theta-burst pairing potentiation