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| Content Provider | PubMed Central |
|---|---|
| Author | Ijdo, Jacob W. Zhang, Yan Anderson, Matthew L. Goldberg, David Erol, Fikrig |
| Copyright Year | 1998 |
| Abstract | We describe a patient with human granulocytic ehrlichiosis (HGE), a diagnosis confirmed by PCR and immunoblot analysis. Unexpectedly, immunoglobulin G (IgG) directed towards an 80-kDa ehrlichial antigen (without detectable IgM) was present in the patient’s serum in the first week of illness. Lyme disease immunoblots were reactive for IgG (but not IgM), a result indicative of prior exposure to the Lyme disease spirochete. Amino-terminal sequencing revealed that the 80-kDa ehrlichial antigen was an HSP-70 homolog similar to Borrelia burgdorferi HSP-70. We conclude that antibodies against B. burgdorferi HSP-70 may cross-react with the ehrlichial heat shock protein and that this possibility must be considered when serologic test results for HGE and Lyme disease are interpreted. |
| Starting Page | 118 |
| File Format | |
| ISSN | 10986588 |
| e-ISSN | 10986588 |
| Journal | Clinical and Diagnostic Laboratory Immunology |
| Issue Number | 1 |
| Volume Number | 5 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 1998-01-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Clinical Biochemistry Immunology Microbiology (medical) |
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