NDLI: Flamenco, a Gene Controlling the Gypsy Retrovirus of Drosophila Melanogaster

Content Provider	PubMed Central
Author	Prud'homme, N. Gans, M. Masson, M. Terzian, C. Bucheton, A.
Abstract	Gypsy is an endogenous retrovirus of Drosophila melanogaster. It is stable and does not transpose with detectable frequencies in most Drosophila strains. However, we have characterized unstable strains, known as MG, in which it transposes at high frequency. These stocks contain more copies of gypsy than usual stocks. Transposition results in mutations in several genes such as ovo and cut. They are stable and are due to gypsy insertions. Integrations into the ovo(D1) female sterile-dominant mutation result in a null allele of the gene and occurrence of fertile females. This phenomenon, known as the ovo(D1) reversion assay, can be used to quantitate gypsy activity. We have shown that the properties of MG strains result from mutation of a host gene that we called flamenco (flam). It has a strict maternal effect on gypsy mobilization: transposition occurs at high frequency only in the germ line of the progeny of females homozygous for mutations of the gene. It is located at position 65.9 (20A1-3) on the X chromosome. The mutant allele present in MG strains is essentially recessive. Flamenco seems to control the infective properties of gypsy.
Starting Page	697
File Format	PDF
ISSN	00166731
Journal	Genetics
Issue Number	2
Volume Number	139
Language	English
Publisher Date	1995-02-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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Flamenco, a Gene Controlling the Gypsy Retrovirus of Drosophila Melanogaster