NDLI: Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice

Content Provider	PubMed Central
Author	Lu, Fangli Huang, Shiguang Hu, Mark S. Kasper, Lloyd H.
Copyright Year	2005
Abstract	Genetic factors determining the pathogenesis and course of ocular toxoplasmosis are poorly understood. In this study, we explored the development of experimental ocular pathogenesis in genetically dissimilar mice infected with either the RH strain, the PLK strain, or the immunodominant surface antigen 1 (SAG1 [P30])-deficient mutant of the RH strain of Toxoplasma gondii. At 11 days postinfection, ocular infection of C57BL/6 mice with all of the strains of parasites resulted in severe inflammatory lesions and high numbers of parasites in eye tissue; less severe ocular lesions at earlier histopathology and prolonged survival were observed in this mouse strain infected with either the major surface antigen 1-deficient SAG1−/− strain or the less virulent PLK strain compared with RH infection. In contrast, both BALB/c and CBA/J mice had less severe lesions and low numbers of parasites in their eye tissue, and infection developed into the chronic stage in these mice. There were significantly higher serum levels of gamma interferon and tumor necrosis factor alpha in C57BL/6 mice than in BALB/c and CBA/J mice following ocular infection. These observations confirm earlier reports on systemic immunity to these parasites that the route of Toxoplasma infection markedly influences survival of mice. Our data indicate that genetic factors of the host as well as the parasite strain are critical in determining susceptibility to experimental ocular toxoplasmosis in murine models.
Related Links	http://dx.doi.org/10.1128/iai.73.8.5160-5165.2005
Ending Page	5165
Page Count	6
Starting Page	5160
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	8
Volume Number	73
Language	English
Publisher	American Society for Microbiology
Publisher Date	2005-08-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice

Mouse hepatitis virus type 4 infection of primary glial cultures from genetically susceptible and resistant mice.

Fowl Immunoglobulins: Quantitation in Birds Genetically Resistant and Susceptible to Marek's Disease

Fowl Immunoglobulins: Quantitation in Birds Genetically Resistant and Susceptible to Marek's Disease

Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice

Analysis of macrophage bactericidal function in genetically resistant and susceptible mice by using the temperature-sensitive mutant of Listeria monocytogenes.

A/J Mice Are Susceptible and C57BL/6 Mice Are Resistant to Listeria monocytogenes Infection by Intragastric Inoculation

Gonococcal infection in endotoxin-resistant and endotoxin-susceptible mice.

CD4+ T Cells in the Pathogenesis of Murine Ocular Toxoplasmosis

Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice

Similar Documents

Neutrophil Responses to Mycobacterium tuberculosis Infection in Genetically Susceptible and Resistant Mice

Mouse hepatitis virus type 4 infection of primary glial cultures from genetically susceptible and resistant mice.

Fowl Immunoglobulins: Quantitation in Birds Genetically Resistant and Susceptible to Marek's Disease

Fowl Immunoglobulins: Quantitation in Birds Genetically Resistant and Susceptible to Marek's Disease

Fas-FasL Interaction Involved in Pathogenesis of Ocular Toxoplasmosis in Mice

Analysis of macrophage bactericidal function in genetically resistant and susceptible mice by using the temperature-sensitive mutant of Listeria monocytogenes.

A/J Mice Are Susceptible and C57BL/6 Mice Are Resistant to Listeria monocytogenes Infection by Intragastric Inoculation

Gonococcal infection in endotoxin-resistant and endotoxin-susceptible mice.

CD4+ T Cells in the Pathogenesis of Murine Ocular Toxoplasmosis

Experimental Ocular Toxoplasmosis in Genetically Susceptible and Resistant Mice