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Role of Apo2L/TRAIL and Bcl-2-family Proteins in Apoptosis of Multiple Myeloma*
| Content Provider | PubMed Central |
|---|---|
| Author | Chen, Quan Ray, Subrata Hussein, Mohamad A. Gordan, Srkalovic Alexandru, Almasan |
| Abstract | Apo2 Ligand or Tumour Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (Apo2L/TRAIL) is a member of the TNF gene superfamily that selectively induces apoptosis in tumor cells of diverse origins through engagement of death receptors. We have recently demonstrated that Type I interferons (IFN-α and β) induce apoptosis in multiple myeloma (MM) cell lines and in plasma cells from MM patients. Moreover, Apo2L selectively induces apoptosis of patient MM tumor cells while sparing non-malignant cells. Apo2L induction is one of the earliest events following IFN administration in these cells. IFNs activate Caspases and the mitochondrial-dependent apoptotic pathway mediated by Apo2L production. Cell death induced by IFNs and Apo2L can be blocked by a dominant-negative Apo2L receptor, DR5, and is regulated by members of the Bcl-2 family of proteins. This review is focused on the apoptotic signaling pathways regulated by Apo2L and Bcl-2-family proteins and summarizes what is known about their clinical role. |
| Related Links | http://dx.doi.org/10.1080/1042819031000068052 |
| Ending Page | 1214 |
| Page Count | 6 |
| Starting Page | 1209 |
| File Format | |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| Journal | Leukemia & lymphoma |
| Issue Number | 7 |
| Volume Number | 44 |
| Language | English |
| Publisher Date | 2003-07-01 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
