NDLI: Loss and gain of chromosome 5 controls growth of Candida albicans on sorbose due to dispersed redundant negative regulators

Content Provider	PubMed Central
Author	Kabir, M. Anaul Ahmad, Ausaf Greenberg, Jay R. Wang, Ying-kai Elena, Rustchenko
Copyright Year	2005
Abstract	A reversible decrease or increase of Candida albicans chromosome copy number was found to be a prevalent means of survival of this opportunistic pathogen, under conditions that kill cells or inhibit their propagation. The utilization of a secondary carbon source, l-sorbose, by reversible loss of chromosome 5, serves as a model system. We have determined that an ≈209-kbp portion of the right arm of chromosome 5 contains at least five spatially separated, functionally redundant regions that control utilization of l-sorbose. The regions bear no structural similarity among themselves, and four of them contain sequences that bear no similarity with any known sequence. We identified a regulatory gene in region A that encodes a helix-loop-helix protein. Most important, the multiple redundant regulators scattered along chromosome 5 explain, in a simple, elegant way, why the loss of the entire homologue is usually required for growth on sorbose. Thus, an entire chromosome acts as a single regulatory unit, a feature not previously considered. Our finding appears to be a paradigm for the control of other phenotypes in C. albicans that also depend on chromosome loss, thus implying that C. albicans genes are not distributed randomly among different chromosomes.
Related Links	http://dx.doi.org/10.1073/pnas.0505625102
Ending Page	12152
Page Count	6
Starting Page	12147
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	34
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-08-23
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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