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| Content Provider | PubMed Central |
|---|---|
| Author | Soffe, S. R. |
| Abstract | 1. Properties of rhythmic, compound mid-cycle inhibitory post-synaptic potentials (i.p.s.p.s), which constitute one of the three main synaptic drives to motoneurones during fictive swimming in Xenopus embryos, have been examined using ionic and pharmacological manipulation. 2. Mid-cycle i.p.s.p.s are Cl- dependent. They are reversed by intracellular Cl- injection and attenuated by lowered extracellular Cl- concentration. 3. In response to bath application of 100 microM-glycine or 100 microM-gamma-aminobutyric acid (GABA), motoneurones show a decrease in cell input resistance of 24 +/- 2.9 M omega (mean +/- S.E. of mean) or 16 +/- 3.7% and 26 +/- 6.0 M omega or 14 +/- 2.0% respectively. This is associated with a weak hyperpolarization or depolarization of 0 +/- 1.5 mV and -3 +/- 1.4 mV respectively. Both responses can be made strongly depolarizing by intracellular Cl- injection. 4. The response to glycine is blocked by 1 microM-strychnine but is largely unaffected by bicuculline below 50 microM. The response to GABA is largely blocked by 10 microM-bicuculline but is unaffected by 1 microM-strychnine. Both strychnine and bicuculline are therefore specific antagonists in the amphibian embryo preparation. Glycine and GABA are both partially antagonized by 10 microM-picrotoxin. 5. Mid-cycle i.p.s.p.s recorded in motoneurones during fictive swimming are reduced in amplitude by 0.5-1 microM-strychnine but are largely unaffected by 40 microM-bicuculline. In embryos immobilized by ventral root transection, 100 microM-tubocurarine, a likely GABA antagonist in the embryo, has no effect on mid-cycle inhibition. Glycine is suggested to be the probable transmitter released by commissural interneurones and mediating mid-cycle inhibition during fictive swimming, acting to increase conductance of Cl-. |
| Ending Page | 473 |
| Starting Page | 463 |
| File Format | |
| ISSN | 14697793 |
| e-ISSN | 14697793 |
| Journal | The Journal of Physiology |
| Volume Number | 382 |
| Language | English |
| Publisher Date | 1987-01-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Sports Science |
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