NDLI: Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase

Content Provider	PubMed Central
Author	Hibuse, Toshiyuki Maeda, Norikazu Funahashi, Tohru Yamamoto, Kaori Nagasawa, Azumi Mizunoya, Wataru Kishida, Ken Inoue, Kazuo Kuriyama, Hiroshi Nakamura, Tadashi Fushiki, Tohru Kihara, Shinji Shimomura, Iichiro
Copyright Year	2005
Abstract	In adipocytes, hydrolysis of triglycerides results in the release of free fatty acids and glycerol. Aquaporin 7 (AQP7), a member of aquaglyceroporins, is known to permeabilize glycerol and water. We recently generated Aqp7-knockout (KO) mice and demonstrated that such mice have low plasma glycerol levels and impaired glycerol release in response to β3-adrenergic agonist, suggesting that AQP7 acts as a glycerol gateway molecule in adipocytes for the efficient release of glycerol in vivo. Although there was no difference in body weight between WT and KO mice until 10 weeks of age, here we found that KO mice developed adult-onset obesity. The body weight and fat mass increased significantly in KO mice compared with WT mice after 12 weeks of age. Adipocytes of KO mice were large and exhibited accumulation of triglycerides compared with WT mice. The KO mice developed obesity and insulin resistance even at a young age after consumption of high-fat/high-sucrose diet. We demonstrated the enhanced glycerol kinase enzymatic activity in Aqp7-KO and -knockdown adipocytes. A series of our results indicate that AQP7 disruption elevates adipose glycerol kinase activity, accelerates triglycerides synthesis in adipocytes, and, finally, develops obesity.
Related Links	http://dx.doi.org/10.1073/pnas.0503291102
Starting Page	10993
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	31
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-08-02
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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