NDLI: Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3

Content Provider	PubMed Central
Author	Kang, Jong Seok Alliston, Tamara Rachel, Delston Derynck, Rik
Copyright Year	2005
Abstract	Transforming growth factor-β (TGF-β) inhibits osteoblast differentiation through inhibition of the function of Runx2 (Cbfa1) by Smad3. The mechanism through which TGF-β/Smad3 inhibits Runx2 function has not been characterized. We show that TGF-β induces histone deacetylation, primarily of histone H4, at the osteocalcin promoter, which is repressed by TGF-β, and that histone deacetylation is required for repression of Runx2 by TGF-β. This repression occurs through the action of the class IIa histone deacetylases (HDAC)4 and 5, which are recruited through interaction with Smad3 to the Smad3/Runx2 complex at the Runx2-binding DNA sequence. Accordingly, HDAC4 or 5 is required for efficient TGF-β-mediated inhibition of Runx2 function and is involved in osteoblast differentiation. Our results indicate that class IIa HDACs act as corepressors for TGF-β/Smad3-mediated transcriptional repression of Runx2 function in differentiating osteoblasts and are cell-intrinsic regulators of osteoblast differentiation.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7600729
Ending Page	2555
Page Count	13
Starting Page	2543
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	14
Volume Number	24
Language	English
Publisher Date	2005-06-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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