NDLI: Control of T helper 2 cell function and allergic airway inflammation by PKCζ

Content Provider	PubMed Central
Author	Martin, Pilar Villares, Ricardo Sandra, Rodriguez-mascarenhas Zaballos, Angel Michael, Leitges Kovac, Judit Irene, Sizing Rennert, Paul Márquez, Gabriel Carlos, Martínez-a Diaz Meco, María T. Jorge, Moscat
Copyright Year	2005
Abstract	Asthma is a disease of chronic airway inflammation in which T helper (Th) 2 cells play a critical role. The molecular mechanisms controlling Th2 differentiation and function are of paramount importance in biology and immunology. PKCζ has been implicated in the regulation of apoptosis and NF-κB, as well as in the control of T-dependent responses, although no defects were detected in naïve T cells from PKCζ–/– mice. Here, we report that PKCζ is critical for IL-4 signaling and Th2 differentiation. Thus, PKCζ levels are increased during Th2 differentiation, but not Th1 differentiation, of CD4+ T cells, and the loss of PKCζ impairs the secretion of Th2 cytokines in vitro and in vivo, as well as the nuclear translocation and tyrosine phosphorylation of Stat6 and Jak1 activation, essential downstream targets of IL-4 signaling. Moreover, PKCζ–/– mice display dramatic inhibition of ovalbumin-induced allergic airway disease, strongly suggesting that PKCζ can be a therapeutic target in asthma.
Related Links	http://dx.doi.org/10.1073/pnas.0501202102
Ending Page	9871
Page Count	6
Starting Page	9866
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	28
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-07-12
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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