NDLI: Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.

Content Provider	PubMed Central
Author	Chantalat, L. Leroy, D. Filhol, O. Nueda, A. Benitez, M. J. Chambaz, E. M. Cochet, C. Dideberg, O.
Abstract	Protein kinase CK2 is a tetramer composed of two alpha catalytic subunits and two beta regulatory subunits. The structure of a C-terminal truncated form of the human beta subunit has been determined by X-ray crystallography to 1.7 A resolution. One dimer is observed in the asymmetric unit of the crystal. The most striking feature of the structure is the presence of a zinc finger mediating the dimerization. The monomer structure consists of two domains, one entirely alpha-helical and one including the zinc finger. The dimer has a crescent shape holding a highly acidic region at both ends. We propose that this acidic region is involved in the interactions with the polyamines and/or catalytic subunits. Interestingly, conserved amino acid residues among beta subunit sequences are clustered along one linear ridge that wraps around the entire dimer. This feature suggests that protein partners may interact with the dimer through a stretch of residues in an extended conformation.
Related Links	http://dx.doi.org/10.1093/emboj/18.11.2930
Ending Page	2940
Page Count	11
Starting Page	2930
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	11
Volume Number	18
Language	English
Publisher Date	1999-06-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation.

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit

Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.

Similar Documents

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation.

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex

Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit

Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.