NDLI: A viral activator of gene expression functions via the ubiquitin-proteasome pathway.

Content Provider	PubMed Central
Author	Everett, R. D. Orr, A. Preston, C. M.
Abstract	The ability of herpes simplex virus type 1 (HSV-1) to attain a latent state in sensory neurones and reactivate periodically is crucial for its biological and clinical properties. The active transcription of the entire 152 kb viral genome during lytic replication contrasts with the latent state, which is characterized by the production of a single set of nuclear-retained transcripts. Reactivation of latent genomes to re-initiate the lytic cycle therefore involves a profound change in viral transcriptional activity, but the mechanisms by which this fundamentally important process occurs are yet to be well understood. In this report we show that the stimulation of the onset of viral lytic infection mediated by the viral immediate-early (IE) protein Vmw110 is strikingly inhibited by inactivation of the ubiquitin-proteasome pathway. Similarly, the Vmw110-dependent reactivation of quiescent viral genomes in cultured cells is also dependent on proteasome activity. These results constitute the first demonstration that the transcriptional activity of a viral genome can be regulated by protein stability control pathways.
Related Links	http://dx.doi.org/10.1093/emboj/17.24.7161
Ending Page	7169
Page Count	9
Starting Page	7161
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	24
Volume Number	17
Language	English
Publisher Date	1998-12-15
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Distinct functions of the ubiquitin–proteasome pathway influence nucleotide excision repair

The ubiquitin-proteasome pathway: on protein death and cell life.

Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin–proteasome pathway

Regulation of nicotinic receptor expression by the ubiquitin–proteasome system

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

PA200, a nuclear proteasome activator involved in DNA repair

SSRP1 functions as a co-activator of the transcriptional activator p63

Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression

A viral activator of gene expression functions via the ubiquitin-proteasome pathway.

Similar Documents

Distinct functions of the ubiquitin–proteasome pathway influence nucleotide excision repair

The ubiquitin-proteasome pathway: on protein death and cell life.

Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin–proteasome pathway

Regulation of nicotinic receptor expression by the ubiquitin–proteasome system

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway

PA200, a nuclear proteasome activator involved in DNA repair

SSRP1 functions as a co-activator of the transcriptional activator p63

Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression

A viral activator of gene expression functions via the ubiquitin-proteasome pathway.