NDLI: Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts

Content Provider	PubMed Central
Author	Nishikawa, Hiroyoshi Kato, Takuma Tawara, Isao Takemitsu, Tetsushi Saito, Kanako Wang, Linan Ikarashi, Yoshinori Wakasugi, Hiro Nakayama, Toshinori Taniguchi, Masaru Kuribayashi, Kagemasa Old, Lloyd J. Hiroshi, Shiku
Copyright Year	2005
Abstract	We examined the role of CD4+CD25+ regulatory T cells in the development of 3-methylcholanthrene (MCA)-induced tumors. Immunization of wild-type BALB/c mice with a series of SEREX (serological identification of antigens by recombinant expression cloning)-defined broadly expressed self-antigens results in the development of highly active CD4+CD25+ regulatory T cells. Accelerated tumor development was observed in mice immunized with self-antigens and was abolished by antibody-mediated depletion of CD4+ T cells or CD25+ T cells. A similar acceleration of tumorigenesis was also observed in mice adoptively transferred 2 or 4 weeks after MCA injection with CD4+CD25+ T cells derived from mice immunized with DnaJ-like 2, one of these self-antigens. Experiments with Jα281-/- mice lacking invariant natural killer (iNK) T cells indicated that iNK T cells, known for their protective role in the development of MCA-induced tumors, were suppressed in immunized hosts. NK cells, also known to play a protective role in MCA induced-tumorigenesis, were also suppressed in mice immunized with serologically defined self-antigens in a CD4+CD25+ T cell-dependent manner. We propose that CD4+CD25+ regulatory T cells generated by immunization with these self-antigens enhance susceptibility to MCA induced-tumorigenesis by down-regulating iNK T and NK reactivity, and suggest that these observations provide direct evidence for the existence of cancer immunosurveillance in this system of chemical carcinogenesis.
Related Links	http://dx.doi.org/10.1073/pnas.0503852102
Ending Page	9257
Page Count	5
Starting Page	9253
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	26
Volume Number	102
Language	English
Publisher	National Academy of Sciences
Publisher Date	2005-06-28
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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