NDLI: Reaction of artemisinin with haemoglobin: implications for antimalarial activity

Content Provider	PubMed Central
Author	Kannan, Rangiah Kumar, Krishan Dinkar, Sahal Kukreti, Shrikant Chauhan, Virander S.
Copyright Year	2005
Abstract	Elucidation of the principal targets of the action of the antimalarial drug artemisinin is an ongoing pursuit that is important for understanding the action of this drug and for the development of more potent analogues. We have examined the chemical reaction of Hb with artemisinin. The protein-bound haem in Hb has been found to react with artemisinin much faster than is the case with free haem. It appears that the uptake of Hb and the accumulation of artemisinin into the food vacuole, together with the preferred reactivity of artemisinin with haem in Hb, may make Hb the primary target of artemisinin's antimalarial action. Both monoalkylated (HA) and dialkylated (HAA) haem derivatives of artemisinin have been isolated. These ‘haemarts’ bind to PfHRP II (Plasmodium falciparum histidine-rich protein II), inhibiting haemozoin formation, and possess a significantly decreased ability to oxidize ascorbic acid. The accelerated formation of HAA from Hb is expected to decrease the ratio of haem to its alkylated derivatives. The haemarts that are generated from ‘haemartoglobins’ may bring about the death of malaria parasite by a two-pronged effect of stalling the formation of haemozoin by the competitive inhibition of haem binding to its templates and creating a more reducing environment that is not conducive to the formation of haemozoin.
Related Links	http://dx.doi.org/10.1042/bj20041170
Ending Page	418
Page Count	10
Starting Page	409
File Format	PDF
ISSN	02646021
e-ISSN	14708728
Journal	Biochemical Journal
Issue Number	Pt 2
Volume Number	385
Language	English
Publisher	Portland Press Ltd.
Publisher Date	2005-01-15
Access Restriction	Open
Rights Holder	Portland Press Ltd.
Subject Keyword	Cell Biology Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Aromatic amino analogues of artemisinin: synthesis and in vivo antimalarial activity

The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin

Antimalarial Activity of Cupredoxins

A SAR and QSAR Study of New Artemisinin Compounds with Antimalarial Activity

PG12, a Phospholipid Analog with Potent Antimalarial Activity, Inhibits Plasmodium falciparum CTP:Phosphocholine Cytidylyltransferase Activity*

Thermochemistry of the oxygen-haemoglobin reaction

The reaction of normal adult human haemoglobin with heavy-metal reagents

The reaction of menadione with haemoglobin. Mechanism and effect of superoxide dismutase.

Calorimetric studies of the haemoglobin–haptoglobin reaction

Reaction of artemisinin with haemoglobin: implications for antimalarial activity

Similar Documents

Aromatic amino analogues of artemisinin: synthesis and in vivo antimalarial activity

The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin

Antimalarial Activity of Cupredoxins

A SAR and QSAR Study of New Artemisinin Compounds with Antimalarial Activity

PG12, a Phospholipid Analog with Potent Antimalarial Activity, Inhibits Plasmodium falciparum CTP:Phosphocholine Cytidylyltransferase Activity*

Thermochemistry of the oxygen-haemoglobin reaction

The reaction of normal adult human haemoglobin with heavy-metal reagents

The reaction of menadione with haemoglobin. Mechanism and effect of superoxide dismutase.

Calorimetric studies of the haemoglobin–haptoglobin reaction

Reaction of artemisinin with haemoglobin: implications for antimalarial activity