NDLI: Multiple pathways contribute to nuclear import of core histones

Content Provider	PubMed Central
Author	Petra, Mühlhäusser Müller, Eva-christina Otto, Albrecht Kutay, Ulrike
Copyright Year	2001
Abstract	Nuclear import of the four core histones H2A, H2B, H3 and H4 is one of the main nuclear import activities during S-phase of the cell cycle. However, the molecular machinery facilitating nuclear import of core histones has not been elucidated. Here, we investigated the pathways by which histone import can occur. First, we show that core histone import can be competed by the BIB (β-like import receptor binding) domain of ribosomal protein L23a suggesting that histone import is an importin mediated process. Secondly, affinity chromatography on immobilized core histones revealed that several members of the importin β family of transport receptors are able to interact with core histones. Finally, we demonstrate that at least four known and one novel importin, importin 9, can mediate nuclear import of core histones into the nuclei of permeabilized cells. Our results suggest that multiple pathways of import exist to provide efficient nuclear uptake of these abundant, essential proteins.
Related Links	http://dx.doi.org/10.1093/embo-reports/kve168
Ending Page	696
Page Count	7
Starting Page	690
File Format	PDF
ISSN	1469221X
e-ISSN	14693178
Journal	EMBO Reports
Issue Number	8
Volume Number	2
Language	English
Publisher	Oxford University Press
Publisher Date	2001-08-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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