NDLI: New linkage data for the X-linked types of muscular dystrophy and G6PD variants, colour blindness, and Xg blood groups

Content Provider	PubMed Central
Author	Zatz, Mayana Itskan, Sueli B. Sanger, Ruth Frota-pessoa, O. Saldanha, P. H.
Abstract	Six families in which Duchenne muscular dystrophy (DMD) and G6PD or deutan colour blindness are segregating are reported. The sum of the lod-scores of these families together with three published previously indicates that the DMD locus is far from the G6PD:deutan cluster. The lod-scores of two families with Becker muscular dystrophy (BMD) informative for the G6PD locus together with those of one family previously studied by Emery, Smith, and Sanger (1969) suggest that the BMD locus could be at a measurable distance from this cluster. The maximum likelihood estimate of the recombination fraction is 0·27 and the 90% confidence limits are 0·17 and 0·40. This difference in linkage estimates for DMD and BMD suggests that the BMD and the DMD genes are located at two different loci on the X chromosome.
Starting Page	321
File Format	PDF
ISSN	14686244
e-ISSN	14686244
Journal	Journal of Medical Genetics
Issue Number	4
Volume Number	11
Language	English
Publisher Date	1974-12-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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New linkage data for the X-linked types of muscular dystrophy and G6PD variants, colour blindness, and Xg blood groups