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| Content Provider | PubMed Central |
|---|---|
| Author | Yamada, Hiroyuki Mizuno, Satoru Reza-gholizadeh, Md Sugawara, Isamu |
| Editor | Barbieri, J. T. |
| Copyright Year | 2001 |
| Abstract | To understand the role of NF-κB in the development of murine tuberculosis in vivo, NF-κB p50 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne-infection apparatus. These mice developed multifocal necrotic pulmonary lesions or lobar pneumonia. Compared with the levels in wild-type mice, pulmonary inducible nitric oxide synthase, interleukin-2 (IL-2), gamma interferon, and tumor necrosis factor alpha mRNA levels were significantly low but expression of IL-10 and transforming growth factor β mRNAs were within the normal ranges. The pulmonary IL-6 mRNA expression level was higher. Therefore, NF-κB and its interaction with host cells play an important role in the pathogenesis of tuberculosis. |
| Related Links | http://dx.doi.org/10.1128/iai.69.11.7100-7105.2001 |
| Ending Page | 7105 |
| Page Count | 6 |
| Starting Page | 7100 |
| File Format | |
| ISSN | 00199567 |
| e-ISSN | 10985522 |
| Journal | Infection and Immunity |
| Issue Number | 11 |
| Volume Number | 69 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2001-11-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology |
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