NDLI: A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression

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A novel resting-state functional magnetic resonance imaging signature of resilience to recurrent depression

Content Provider	PsyArXiv
Author	Workman, Clifford Ian Lythe, Karen E. McKie, Shane Moll, Jorge Gethin, Jennifer A. Deakin, John F. W. Elliott, Rebecca Zahn, Roland
Description	Background: A high proportion of patients with remitted major depressive disorder (MDD) will experience recurring episodes, whilst some develop resilience and remain in recovery. The neural basis of resilience to recurrence is elusive. Abnormal resting-state connectivity of the subgenual cingulate cortex (sgACC) was previously found in cross-sectional studies of MDD, suggesting its potential pathophysiological importance. The current study aimed to investigate whether resting-state connectivity to a left sgACC seed region distinguishes resilient patients from those developing recurring episodes. Method: A total of 47 medication-free remitted MDD patients and 38 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) at baseline. Over 14 months, 30 patients remained resilient whilst 17 experienced a recurring episode. Results: Attenuated interhemispheric left-to-right sgACC connectivity distinguished the resilient from the recurring-episode and control groups and was not correlated with residual depressive symptoms. Conclusions: The current study revealed a neural signature of resilience to recurrence in MDD and thereby elucidates the role of compensatory adaptation in sgACC networks.
DOI	10.31234/osf.io/f8msc
Language	English
Publisher Date	2021-03-20
Access Restriction	Open
Rights License	CC-By Attribution 4.0 International
Subject Keyword	Psychiatry;Neuroscience;Clinical Neuroscience Clinical Neuroscience Depression Major Depression Mood Disorders Neuropsychiatry Remission Remitted Depression Resilience Resting Fmri Resting-state Resting-state Fmri Rsfmri Sgacc Subgenual Cingulate Subgenual Cingulate Cortex
Content Type	Text
Resource Type	Preprint
Subject	Psychiatry and Mental Health Neuroscience Neurology (clinical)

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