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t(8;21)(q22;q22) in Blast Phase of Chronic Myelogenous Leukemia
| Content Provider | Paperity |
|---|---|
| Author | Medeiros, L. Jeffrey Lin, Pei Yin, C. Cameron Glassman, Armand B. |
| Abstract | The blast phase of chronic myelogenous leukemia (CML) frequently is associated with cytogenetic evidence of clonal evolution, defined as chromosomal aberrations in addition to the t(9;22)(q34;q11.2). We identified the t(8;21)(q22;q22) and other cytogenetic abnormalities by conventional cytogenetics and fluorescence in situ hybridization in 2 patients with t(9;22)-positive CML at the time of blast phase. The t(8;21), which typically is associated with a distinct subtype of de novo acute myeloid leukemia (AML) carrying the <italic>aml1/eto</italic> fusion gene, was accompanied by increased bone marrow myeloblasts (33%) in case 1 and extramedullary myeloid sarcoma in case 2, suggesting its possible role in disease progression. In case 1, the leukemic cells in aspirate smears had salmon-colored cytoplasmic granules, and immunophenotypic studies showed that the blasts expressed CD19. These findings suggest that the pathologic features of blast phase CML with the t(8;21) resemble those of de novo AML with the t(8;21). |
| Starting Page | 836 |
| Ending Page | 842 |
| File Format | HTM / HTML |
| ISSN | 00029173 |
| DOI | 10.1309/H8JH6L094B9U3HGT |
| Issue Number | 6 |
| Journal | American Journal of Clinical Pathology |
| Volume Number | 121 |
| e-ISSN | 19437722 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2004-06-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
