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Cervical ultrasonography has no additional value over negative 18F-FDG PET/CT scans for diagnosing cervical lymph node metastases in patients with oesophageal cancer
| Content Provider | Paperity |
|---|---|
| Author | Marnix, G. E. H. Lam Hillegersberg, Richard Van Ruurda, Jelle P. Peter, S. N. Van Rossum Meziani, Jihane Goense, Lucas Wessels, Frank J. |
| Abstract | Objectives To investigate the additional value of cervical ultrasonography over 18F-FDG PET/CT for diagnosing cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. Methods Between January 2013 and January 2016, 163 patients with newly diagnosed oesophageal cancer underwent both cervical ultrasonography and 18F-FDG PET/CT at a tertiary referral centre in the Netherlands. Retrospective clinical data analysis was performed to assess the diagnostic value of cervical ultrasonography and 18F-FDG PET/CT for the detection of cervical lymph node metastases. Fine needle aspiration or clinical follow-up was used as reference standard. Results The overall incidence of patients with cervical lymph node metastases was 14%. The sensitivity of 18F-FDG PET/CT to detect cervical lymph node metastases was 82% (95% CI 59–94%) and specificity was 91% (95% CI 85–95%). The sensitivity and specificity of cervical ultrasonography were 73% (95% CI 50–88%) and 84% (95% CI 77–90%), respectively. In patients with a negative 18F-FDG PET/CT, 12 of 133 (9%) patients had suspicious nodes on cervical ultrasonography. In all these 12 patients the nodes were confirmed benign. Conclusions Cervical ultrasonography has no additional diagnostic value to a negative integrated 18F-FDG PET/CT for the detection of cervical lymph node metastases in patients with newly diagnosed oesophageal cancer. Key Points • Cervical ultrasonography has no value over PET/CT in evaluating cervical node metastases. • PET/CT provides greater diagnostic confidence compared to cervical ultrasonography. • Cervical ultrasonography during standard diagnostic work-up may be considered unnecessary. • Cervical lesions on PET/CT require cytopathological confirmation by FNA. |
| Starting Page | 1 |
| Ending Page | 7 |
| File Format | HTM / HTML |
| ISSN | 09387994 |
| DOI | 10.1007/s00330-017-5136-x |
| Journal | European Radiology |
| e-ISSN | 14321084 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2017-12-07 |
| Access Restriction | Open |
| Subject Keyword | Oesophageal cancer 18f-fdg positron emission tomography/computed tomography Cervical lymph node metastases Cervical ultrasonography Cancer staging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging |
