NDLI: HERBICIDE PHOSPHINOTHRICIN CAUSES DIRECT STIMULATION HORMESIS

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HERBICIDE PHOSPHINOTHRICIN CAUSES DIRECT STIMULATION HORMESIS

Content Provider	Paperity
Author	Nikolic, Radomirka Dragicevic, Milan Mitic, Nevena Platisa, Jelena Todorovic, Sladana Bogdanovic, Milica Simonovic, Ana
Abstract	Herbicide phosphinothricin (PPT) inhibits glutamine synthetase (GS), a key enzyme in nitrogen assimilation, thus causing ammonia accumulation, glutamine depletion and eventually plant death. However, the growth response of Lotus corniculatus L. plants immersed in solutions with a broad range of PPT concentrations is biphasic, with pronounced stimulating effect on biomass production at concentrations ≤ 50 μM and growth inhibition at higher concentrations. The growth stimulation at low PPT concentrations is a result of activation of chloroplastic isoform GS2, while the growth suppression is caused by inhibition of both cytosolic GS1 and GS2 at higher PPT concentrations. Since the results are obtained in cell-free system (e.g. protein extracts), to which the principles of homeostasis are not applicable, this PPT effect is an unambiguous example of direct stimulation hormesis. A detailed molecular mechanism of concentration-dependent interaction of both PPT and a related GS inhibitor, methionine sulfoximine, with GS holoen- zymes is proposed. The mechanism is in concurrence with all experimental and literature data.
File Format	HTM / HTML
Issue Number	3
Journal	Dose-Response: An International Journal
Volume Number	11
Language	English
Publisher	University of Massachusetts - Amherst
Publisher Date	2013-12-31
Access Restriction	Open
Subject Keyword	Methionine sulfoximine Glutamine synthetase Hormesis Phosphinothricin Glufosinate Lotus corniculatus l.
Content Type	Text
Resource Type	Article

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