NDLI: A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

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A conserved role of the RSC chromatin remodeler in the establishment of nucleosome-depleted regions

Content Provider	Paperity
Author	Vázquez, Enrique Yague-sanz, Carlo Sánchez, Mar Antequera, Francisco Hermand, Damien
Abstract	The occupancy of nucleosomes governs access to the eukaryotic genomes and results from a combination of biophysical features and the effect of ATP-dependent remodelling complexes. Most promoter regions show a conserved pattern characterized by a nucleosome-depleted region (NDR) flanked by nucleosomal arrays. The conserved RSC remodeler was reported to be critical to establish NDR in vivo in budding yeast but other evidences suggested that this activity may not be conserved in fission yeast. By reanalysing and expanding previously published data, we propose that NDR formation requires, at least partially, RSC in both yeast species. We also discuss the most prominent biological role of RSC and the possibility that non-essential subunits do not define alternate versions of the complex.
Starting Page	187
Ending Page	193
File Format	HTM / HTML
ISSN	01728083
DOI	10.1007/s00294-016-0642-y
Issue Number	2
Journal	Current Genetics
Volume Number	63
e-ISSN	14320983
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2017-05-01
Access Restriction	Open
Subject Keyword	Chromatin Yeast Rsc Mitosis Nucleosome
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine

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