NDLI: Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice

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Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice

Content Provider	Paperity
Author	Kasztura, Monika Laszkiewicz, Agnieszka Janik, Sylwia Kisielow, Pawel Peczek, Karolina Majkowski, Michal Sniezewski, Lukasz Kobak, Kamil Miazek, Arkadiusz Kapusniak, Violetta Cebrat, Malgorzata
Abstract	NWC is a third gene within recombination activating gene (RAG) locus, which unlike RAG genes is ubiquitously expressed and encodes a unique protein containing three strongly evolutionarily conserved domains not found in any other known protein. To get insight into its function we identified several proteins co-immunoprecipitating with NWC protein and generated new NWC-deficient mice. Here, we present evidence that unlike many other ubiquitously expressed evolutionarily conserved proteins, functional inactivation of NWC does not cause any gross developmental, physiological or reproductive abnormalities and that under physiological conditions NWC may be involved in assembling and functioning of cilia, cell surface organelles found on nearly every eukaryotic cell.
Starting Page	311
Ending Page	319
File Format	HTM / HTML
ISSN	0004069X
DOI	10.1007/s00005-015-0379-1
Issue Number	4
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	64
e-ISSN	16614917
Language	English
Publisher	Springer International Publishing
Publisher Date	2016-08-01
Access Restriction	Open
Subject Keyword	Nwc protein function/partners Nwc-knockout mice Evolutionarily conserved genes Recombination activating gene (rag) locus Cilia
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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on-line at: www.actabp.pl Identification of a novel protein encoded by third conserved gene within RAG locus (2009)

Complexity of transcriptional regulation within the Rag locus: identification of a second Nwc promoter region within the Rag2 intron

Complexity of transcriptional regulation within the Rag locus: identification of a second Nwc promoter region within the Rag2 intron

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Rearrangement of λ Light Chain Genes in Mature B Cells In Vitro and In Vivo. Function of Reexpressed Recombination-activating Gene (RAG) Products

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Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice

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Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice