NDLI: A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock

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A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock

Content Provider	Paperity
Author	Krasnov, George Zemskaya, Nadezhda Shaposhnikov, Mikhail Danilov, Anton Peregudova, Darya Dobrovolskaya, Eugenia Sharapova, Irina Kudryavtseva, Anna Zhikrivetskaya, Svetlana Proshkina, Ekaterina Solovev, Ilya Borisoglebsky, Dmitry Shilova, Lyubov Moskalev, Alexey Snezhkina, Anastasia
Abstract	Background The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood. Results We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C) on an organism's viability indicators (survival and locomotor activity) and transcriptome changes in the Drosophila melanogaster model. All stress factors but cold shock resulted in a decrease of lifespan proportional to the dose of treatment. However, stress-factors affected locomotor activity without correlation with lifespan. Our data revealed both significant similarities and differences in differential gene expression and the activity of biological processes under the influence of stress factors. Conclusions Studied doses of stress treatments deleteriously affect the organism's viability and lead to different changes of both general and specific cellular stress response mechanisms.
Starting Page	S8
File Format	HTM / HTML
Journal	BMC Genomics
Volume Number	16
e-ISSN	14712164
Language	English
Publisher	BMC
Publisher Date	2015-12-16
Access Restriction	Open
Subject Keyword	Ionizing radiation Starvation Cold shock Entomopathogenic fungus Gene expression Survival Lifespan Drosophila melanogaster
Content Type	Text
Resource Type	Article

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