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HIV-1 functional cure: will the dream come true?
| Content Provider | Paperity |
|---|---|
| Author | Ma, Xiancai Chen, Cancan Liu, Chao Zhang, Hui Liu, Bingfeng |
| Abstract | The reservoir of human immunodeficiency virus type 1 (HIV-1), a long-lived pool of latently infected cells harboring replication-competent viruses, is the major obstacle to curing acquired immune deficiency syndrome (AIDS). Although the combination antiretroviral therapy (cART) can successfully suppress HIV-1 viremia and significantly delay the progression of the disease, it cannot eliminate the viral reservoir and the patient must continue to take anti-viral medicines for life. Currently, the appearance of the ‘Berlin patient’, the ‘Boston patients’, and the ‘Mississippi baby’ have inspired many therapeutic strategies for HIV-1 aimed at curing efforts. However, the specific eradication of viral latency and the recovery and optimization of the HIV-1-specific immune surveillance are major challenges to achieving such a cure. Here, we summarize recent studies addressing the mechanisms underlying the viral latency and define two categories of viral reservoir: ‘shallow’ and ‘deep’. We also present the current strategies and recent advances in the development of a functional cure for HIV-1, focusing on full/partial replacement of the immune system, ‘shock and kill’, and ‘permanent silencing’ approaches. |
| File Format | HTM / HTML |
| ISSN | 17417015 |
| Journal | BMC Medicine |
| e-ISSN | 17417015 |
| Language | English |
| Publisher | BMC |
| Publisher Date | 2015-11-01 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine general Medicine/public health, general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
