NDLI: 192IgG-Saporin immunotoxin and ibotenic acid lesions of nucleus basalis and medial septum produce comparable deficits on delayed nonmatching to position in rats

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192IgG-Saporin immunotoxin and ibotenic acid lesions of nucleus basalis and medial septum produce comparable deficits on delayed nonmatching to position in rats

Content Provider	Paperity
Author	Wiley, Ronald G. Lappi, Douglas A. Robinson, John K. Wenk, Gary L. Crawley, Jacqueline N.
Abstract	The recently developed immunotoxin, 192IgG-Saporin (192-SAP), was compared with the standard excitotoxin, ibotenic acid, on two measures: (1) the extent of deficits on performance of a working memory task, delayed nonmatching-to-position (DNMTP), and (2) sensitivity to scopolamine on this task. Rats were extensively pretrained in an operant, spatial DNMTP memory task, then given combined site-specific lesions of the medial septum/diagonal band and nucleus basalis magnocellularis using either ibotenic acid (IBO) or low doses of the selective cholinergic immunotoxin 192-SAP. When compared with sham controls, both IBO and 192-SAP lesioned rats showed significant delay-independent reductions in DNMTP choice accuracy. Both 192-SAP and IBO lesioned rats showed increased sensitivity to a threshold dose of scopolamine, 0.15 mg/kg i.p., on DNMTP, as compared with sham-lesioned controls. When the rats were assessed at 18 weeks postlesioning, levels of choline acetyltransferase were depleted in the hippocampus in both IBO and 192-SAP lesioned groups. These findings suggest that 192-SAP, a cholinergically selective neurotoxin, is as effective as an excitotoxin when microinjected into cholinergic cell bodies of the basal forebrain, producing deficits in behavioral tasks that persist for several weeks.
Starting Page	179
Ending Page	186
File Format	HTM / HTML
ISSN	08896313
DOI	10.3758/BF03327034
Issue Number	3
Journal	Psychobiology
Volume Number	24
Language	English
Publisher	Springer-Verlag
Publisher Date	1996-09-01
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

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