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Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer
| Content Provider | Paperity |
|---|---|
| Author | Wall, Elsken Van Der Meijrink, Helen Paul, J. Van Diest Inne, H. M. Borel Rinkes Karijn, P. M. Suijkerbuijk Margreet, G. E. M. Ausems Pan, Xiaojuan |
| Abstract | The high rate of interval malignancies urges for new screening methods for women at high risk for breast cancer. Nipple aspiration provides direct access to the breast tissue and its DNA, and therefore is a likely candidate, but clinical applications have been limited by the failure to obtain nipple aspiration fluid from most women. We performed oxytocin-assisted nipple aspiration in 90 women at increased risk for breast cancer based on family history or genetic test results (n = 63) and/or previous breast cancer (n = 34). Nipple fluid was obtained from 81/90 women (90%) and bilaterally in 77%. Mean discomfort rating was 0.6 (on a 0–10 scale), which was significantly lower than for mammography or MRI. These findings suggest that a new tool for biomarker detection in oxytocin-assisted nipple fluid of women at high risk for breast cancer is at hand. |
| Starting Page | 321 |
| Ending Page | 325 |
| File Format | HTM / HTML |
| ISSN | 13899600 |
| DOI | 10.1007/s10689-010-9344-7 |
| Issue Number | 3 |
| Journal | Familial Cancer |
| Volume Number | 9 |
| e-ISSN | 15737292 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2010-09-01 |
| Access Restriction | Open |
| Subject Keyword | Screening Breast cancer Nipple aspiration Brca2 Brca1 Early detection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Cancer Research Genetics (clinical) Oncology |
