NDLI: Structure, Activation, and Biology of Calpain

Content Provider	Paperity
Author	Hata, Shoji Sorimachi, Hiroyuki Suzuki, Koichi Kawabata, Yukiko
Abstract	Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential to understand its physiological functions, is discussed on the basis of recent X-ray structural analyses. Further, special features of the structure of calpain 10 that differ from those of typical μ- or m-calpain used in most studies are summarized together with discussion of the physiological function of calpain with respect to type 2 diabetes.
Starting Page	S12
Ending Page	S18
File Format	HTM / HTML
ISSN	00121797
DOI	10.2337/diabetes.53.2007.S12
Issue Number	1
Journal	Diabetes
Volume Number	53
e-ISSN	1939327X
Language	English
Publisher	American Diabetes Association
Publisher Date	2004-02-01
Access Restriction	Open
Subject Keyword	Lgmd2a, limb-girdle muscular dystrophy type 2a
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine

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Structure, Activation, and Biology of Calpain