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EFFICACY OF THREE CHLOROQUINE–PRIMAQUINE REGIMENS FOR TREATMENT OF PLASMODIUM VIVAX MALARIA IN COLOMBIA
| Content Provider | Paperity |
|---|---|
| Author | Ríos, Alexandra Tobón, Alberto Carmona-fonseca, Jaime Piñeros, Juan-gabriel Álvarez, Gonzalo Maestre, Amanda Blair, Silvia |
| Abstract | Plasmodium vivax malaria is an important cause of morbidity in Central and South America. In Colombia, this is the most prevalent malaria infection, representing 75% of the reported cases. To define the efficacy of the chloroquine and primaquine regimen to eliminate hypnozoites and prevent relapses, we conducted a random controlled clinical trial of three primaquine regimens in an open-label study. We evaluated the anti-relapse efficacy of total primaquine doses of 45, 105, and 210 mg administered at a dosage of 15 mg/day in 210 adults with P. vivax infection from the northwestern region of Colombia. Cure rates for blood-stage P. vivax malaria by day 28 of follow-up were 100% in all groups. Post-treatment reappearance of parasitemia during the six months of follow-up was 45%, 36.6% and 17.6%, respectively, for each group. When compared with other groups, administration of 210 mg was a significant protection factor for reappearance of parasitemia in a malaria-endemic area. |
| Starting Page | 605 |
| Ending Page | 609 |
| File Format | HTM / HTML |
| ISSN | 00029637 |
| Issue Number | 4 |
| Journal | The American Journal of Tropical Medicine and Hygiene |
| Volume Number | 75 |
| e-ISSN | 14761645 |
| Language | English |
| Publisher | The American Society of Tropical Medicine and Hygiene |
| Publisher Date | 2006-10-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Parasitology |
