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Changes in Inflammatory Cytokines Are Related to Impaired Glucose Tolerance in Offspring of Type 2 Diabetic Subjects
| Content Provider | Paperity |
|---|---|
| Author | Ruotsalainen, Eija Salmenniemi, Urpu Kainulainen, Sakari Vauhkonen, Ilkka Pihlajamäki, Jussi Punnonen, Kari Laakso, Markku |
| Abstract | OBJECTIVE—We sought to determine whether levels of inflammatory markers and different cytokines are abnormal in nondiabetic offspring of type 2 diabetic subjects. RESEARCH DESIGN AND METHODS—Cytokine levels were measured in 19 healthy control subjects and 129 offspring of patients with type 2 diabetes (109 with normal glucose tolerance [NGT] and 20 with impaired glucose tolerance [IGT]). Insulin sensitivity was determined with the hyperinsulinemic-euglycemic clamp, insulin secretion with the intravenous glucose tolerance test, and abdominal fat distribution with computed tomography. RESULTS—Levels of C-reactive protein and inflammatory cytokines were elevated in nondiabetic offspring of type 2 diabetic subjects. Interleukin (IL)-1β was increased in the NGT group and decreased in the IGT group. In contrast, levels of IL-1 receptor antagonist (IL-1Ra) were increased in both groups. IL-1β and -Ra levels correlated inversely (P < 0.05) with rates of whole-body glucose uptake and IL-1β positively with visceral fat mass (P < 0.05) in normoglycemic offspring. CONCLUSIONS—Nondiabetic offspring of type 2 diabetic subjects have changes in the levels of inflammatory cytokines. The level of IL-1Ra seems to be the most sensitive marker of cytokine response in the pre-diabetic state. |
| Starting Page | 2714 |
| Ending Page | 2720 |
| File Format | HTM / HTML |
| ISSN | 01495992 |
| DOI | 10.2337/dc06-0147 |
| Issue Number | 12 |
| Journal | Diabetes Care |
| Volume Number | 29 |
| e-ISSN | 19355548 |
| Language | English |
| Publisher | American Diabetes Association |
| Publisher Date | 2006-12-01 |
| Access Restriction | Open |
| Subject Keyword | interleukin Il Tnf tumor necrosis factor Wbgu whole-body glucose uptake normal glucose tolerance Ngt Crp c-reactive protein Il-1ra il-1 receptor antagonist impaired glucose tolerance Igt |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Advanced and Specialized Nursing Internal Medicine |
