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Boron neutron capture therapy outcomes for advanced or recurrent head and neck cancer
| Content Provider | Paperity |
|---|---|
| Author | Kato, Ituro Ono, Koji Suzuki, Minoru Maruhashi, Akira Fukushima, Masanori Hiratsuka, Junichi Kinashi, Yuko Yoshimura, Kenichi Masunaga, Shin-ichiro Kimura, Yoshihiro Ariyoshi, Yasunori Sakurai, Yoshinori Aihara, Teruhito Niimi, Miyuki Haginomori, Shin-ichi |
| Abstract | We retrospectively review outcomes of applying boron neutron capture therapy (BNCT) to unresectable advanced or recurrent head and neck cancers. Patients who were treated with BNCT for either local recurrent or newly diagnosed unresectable head or neck cancers between December 2001 and September 2007 were included. Clinicopathological characteristics and clinical outcomes were retrieved from hospital records. Either a combination of borocaptate sodium and boronophenylalanine (BPA) or BPA alone were used as boron compounds. In all the treatment cases, the dose constraint was set to deliver a dose <10–12 Gy-eq to the skin or oral mucosa. There was a patient cohort of 62, with a median follow-up of 18.7 months (range, 0.7–40.8). A total of 87 BNCT procedures were performed. The overall response rate was 58% within 6 months after BNCT. The median survival time was 10.1 months from the time of BNCT. The 1- and 2-year overall survival (OS) rates were 43.1% and 24.2%, respectively. The major acute Grade 3 or 4 toxicities were hyperamylasemia (38.6%), fatigue (6.5%), mucositis/stomatitis (9.7%) and pain (9.7%), all of which were manageable. Three patients died of treatment-related toxicity. Three patients experienced carotid artery hemorrhage, two of whom had coexistent infection of the carotid artery. This study confirmed the feasibility of our dose-estimation method and that controlled trials are warranted. |
| Starting Page | 146 |
| Ending Page | 153 |
| File Format | HTM / HTML |
| ISSN | 04493060 |
| DOI | 10.1093/jrr/rrt098 |
| Issue Number | 1 |
| Journal | Journal of Radiation Research |
| Volume Number | 55 |
| e-ISSN | 13499157 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Head and neck tumors Boron neutron capture therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Health, Toxicology and Mutagenesis Radiation |
