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Propiedades microbiológicas, clasificación y relación estructura-actividad de cefalosporinas e importancia de las cefalosporinas de cuarta generación
| Content Provider | Paperity |
|---|---|
| Author | Sergio, Mella M. Gerardo, Gonzalez R. Helia, Bello T. Claudia, Zemelman M. Mariana, Dominguez Y. Raul, Zemelman Z. |
| Abstract | The cephalosporins are one of the most important types of ß-lactam antibiotics. There are various classifications of these molecules, but the most frecuently used classifies them according to their structures, microbiological properties and historical development: first to fourth generation cephalosporins. Third generation cephalosporins have been extensively used, but the emergence of bacterial resistance, mainly as a consecuence of chromosomal and plasmidial production of ß-lactamases has limited the use of these antibiotics. Fourth generation cephalosporins are characterized by the presence of a cuaternary nitrogen in C3; mantaining the methoxyimino aminothiazolyl in C7. Fourth generation cephalosporins display a high capacity of intracellular penetration through the external membranes of Gram negative rods and a low affinity to enzymes that degrade third generation cephalosporins. Cefepime, a fourth generation cephalosporin, has shown more inhibitory activity against chilean strains of Klebsiella pneumoniae and Escherichia coli that produce extended-spectrum ß-lactamases, than cefotaxime and ceftazidime |
| Starting Page | 7 |
| Ending Page | 19 |
| File Format | HTM / HTML |
| ISSN | 07161018 |
| DOI | 10.4067/S0716-10182001000100002 |
| Issue Number | 1 |
| Journal | Revista chilena de infectología |
| Volume Number | 18 |
| Language | English Spanish |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Public Health, Environmental and Occupational Health |
