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Innovative strategy with potential to increase hemodialysis efficiency and safety
| Content Provider | Paperity |
|---|---|
| Author | Chang, Chun-chao Lin, Hsiu-chen Mai, Fu-der Liu, Yu-chuan Tsai, Hui-yen Lin, Chun-mao Yang, Chih-ping Chen, Hsiao-chien Chen, Hsi-hsien |
| Abstract | Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10−6 cm s−1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells. |
| File Format | HTM / HTML |
| DOI | 10.1038/srep04425 |
| Journal | Scientific Reports |
| Volume Number | 4 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2014-03-21 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
