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Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer
| Content Provider | Paperity |
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| Author | Ohshima, Y. Shino, M. Kanai, Y. Tominaga, H. Oyama, T. Oriuchi, N. Takayasu, Y. Nagamori, S. Toyoda, M. Ishioka, N. S. Kaira, K. Chikamatsu, K. Takahashi, K. Sakakura, K. |
| Abstract | Background:Amino-acid transporters are necessary for the tumour cell growth and survival, and have a crucial role in the development and invasiveness of cancer cells. But, it remains unclear about the prognostic significance of L-type amino-acid transporter 1 (LAT1), system ASC amino-acid transporter-2 (ASCT2), and xCT expression in patients with tongue cancer. We conducted the clinicopathological study to investigate the protein expression of these amino-acid transporters in tongue cancer.Methods:Eighty-five patients with surgically resected tongue cancer were evaluated. Tumour sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, 4F2hc/CD98hc (4F2hc), Ki-67, and microvessel density (MVD) determined by CD34, and p53.Results:L-type amino-acid transporter 1 and 4F2hc were highly expressed in 61% (52 out of 85) and 45% (38 out of 47), respectively. ASC amino-acid transporter-2 and xCT were positively expressed in 59% (50 out of 85) and 21% (18 out of 85), respectively. The expression of both LAT1 and ASCT2 was significantly associated with disease staging, lymph-node metastasis, lymphatic permeation, 4F2hc expression and cell proliferation (Ki-67). xCT expression indicated a significant association with advanced stage and tumour factor. By univariate analysis, disease staging, lymphatic permeation, vascular invasion, LAT1, ASCT2, 4F2hc, and Ki-67 had a significant relationship with overall survival. Multivariate analysis confirmed that LAT1 was an independent prognostic factor for predicting poor prognosis.Conclusions:L-type amino-acid transporter 1 and ASCT2 can serve as a significant prognostic factor for predicting worse outcome after surgical treatment and may have an important role in the development and aggressiveness of tongue cancer. |
| Starting Page | 2506 |
| Ending Page | 2513 |
| File Format | HTM / HTML |
| ISSN | 15321827 |
| DOI | 10.1038/bjc.2014.178 |
| Journal | British Journal of Cancer |
| Volume Number | 110 |
| e-ISSN | 15321827 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2014-04-24 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
