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Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia
| Content Provider | Paperity |
|---|---|
| Author | Lee, Jae-dong Kim, Gi-young Jin, Cheng-yun Park, Cheol Choi, Yung Hyun |
| Abstract | Aim:Pro-inflammatory mediators, such as prostaglandin E2 (PGE2) and nitric oxide (NO), and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and TNF-α, play pivotal roles in brain injuries. The anti-inflammatory properties are known to be associated with significant reductions in pro-inflammatory mediators in brain injuries. In the present study we investigate whether the effects of curcumin on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated BV2 microglia.Methods:Curcumin were administered and their effects on LPS-induced pro-inflammatory mediators were monitored by Western blotting and RT-PCR.Result:Curcumin significantly inhibited the release of NO, PGE2, and pro-inflammatory cytokines in a dose-dependent manner. Curcumin also attenuated the expressions of inducible NO synthase and cyclooxygenase-2 mRNA and protein levels. Moreover, curcumin suppressed NF-κB activation via the translocation of p65 into the nucleus. Our data also indicate that curcumin exerts anti-inflammatory properties by suppressing the transcription of proinflammatory cytokine genes through the NF-κB signaling pathway.Conclusion:Anti-inflammatory properties of curcumin may be useful for treating the inflammatory and deleterious effects of microglial activation in response to LPS stimulation. |
| Starting Page | 1645 |
| Ending Page | 1651 |
| File Format | HTM / HTML |
| DOI | 10.1111/j.1745-7254.2007.00651.x |
| Journal | Acta Pharmacologica Sinica |
| Volume Number | 28 |
| e-ISSN | 17457254 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2007-10-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
