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Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform
| Content Provider | Paperity |
|---|---|
| Author | Raston, Colin L. Mo, Jingxin Yuan, Zhi-xiang Eggers, Paul K. Lim, Lee Yong |
| Abstract | A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX-loaded PCV conjugated with alkyne-modified PEG-folic acid ligands prepared via click ligation (fP-PCVPTX) has enhanced potency against folate receptor (FR)-positive SKOV-3 ovarian tumour cells over FR-negative A549 lung tumour cells. Moreover, fP-PCVPTX is also four times more potent than the non-targeting PCVPTX platform towards SKOV-3 cells. Overall, as a delivery platform the PCVs have the potential to enhance efficacy of anticancer drugs by targeting a chemotherapeutic payload specifically to tumours and triggering the release of the encapsulated drug in the vicinity of cancer cells. |
| File Format | HTM / HTML |
| DOI | 10.1038/srep23489 |
| Journal | Scientific Reports |
| Volume Number | 6 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2016-03-24 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
