Loading...
Please wait, while we are loading the content...
Similar Documents
A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Duliang Soft Capsule in Patients with Chronic Daily Headache
| Content Provider | Paperity |
|---|---|
| Author | Yang, Xiaosu Yu, Tingmin Feng, Jiachun Li, Zhiwei Wan, Qi Liu, Ming Zhou, Jiying Yu, Juming Pan, Xiaoping Dou, Linsen Qiao, Xiangyang Yu, Shengyuan Hu, Yueqing Chen, Kangning Yang, Qingwu Duan, Jingfeng Chen, Yangmei Liu, Xinfeng Bai, Xue |
| Abstract | Objective. To investigate the efficacy and safety of traditional Chinese medicine Duliang soft capsule (DSC) in prophylactic treatment for patients with chronic daily headache (CDH). Methods. A multicenter, double-blind, randomized, placebo-controlled clinical study was conducted at 18 Chinese clinical centers. The participants received either DSC or placebo for 4 weeks. The primary efficacy measure was headache-free rate (HFR) in a 4-week period between the pretreatment and posttreatment stages. The secondary efficacy measures were the decrease of headache days, the duration of headache attacks, the frequency of analgesic usage, quality of life, disability, and the headache severity (VAS scores). The accompanying symptoms and adverse events were also assessed. Results. Of 584 CDH patients assessed, 468 eligible patients were randomized. 338 patients received DSC, while 111 patients were assigned in the placebo group. Following treatment, there was a 16.56% difference in HFR favoring DSC over placebo (). Significant differences were also observed between DSC and placebo groups in the secondary measures. However, no statistical difference was found between the two groups in the associated symptoms. No severe adverse effects were observed in the study. Conclusions. DSC might be an effective and well-tolerated option for the prophylactic treatment of patients with CDH. |
| File Format | HTM / HTML |
| ISSN | 1741427X |
| DOI | 10.1155/2015/694061 |
| Journal | Evidence-Based Complementary and Alternative Medicine |
| Volume Number | 2015 |
| e-ISSN | 17414288 |
| Language | English |
| Publisher | Hindawi Limited |
| Publisher Date | 2015-05-26 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Complementary and Alternative Medicine |
