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How Memory Switches Brain Responses of Patients with Post-traumatic Stress Disorder
| Content Provider | Oxford Academic |
|---|---|
| Author | Inoue, Jun Matsuo, Kayako Iwabuchi, Toshiki Takehara, Yasuo Yamasue, Hidenori |
| Copyright Year | 2021 |
| Abstract | To characterize the brain responses to traumatic memories in post-traumatic stress disorder (PTSD), we conducted task-employed functional magnetic resonance imaging and, in the process, devised a simple but innovative approach—correlation computation between task conditions. A script-driven imagery task was used to compare the responses with a script of the patients' own traumatic memories and with that of tooth brushing as a daily activity and to evaluate how eye movement desensitization and reprocessing (EMDR), an established therapy for PTSD, resolved the alterations in patients. Nine patients with PTSD (seven females, aged 27–50 years) and nine age- and gender-matched healthy controls participated in this study. Six patients underwent the second scan under the same paradigm after EMDR. We discovered intense negative correlations between daily and traumatic memory conditions in broad areas, including the hippocampus; patients who had an intense suppression of activation during daily recognition showed an intense activation while remembering a traumatic memory, whereas patients who had a hyperarousal in daily recognition showed an intense suppression while remembering a traumatic memory as a form of “shut-down.” Moreover, the magnitude of the discrepancy was reduced in patients who remitted after EMDR, which might predict an improved prognosis of PTSD. |
| Related Links | https://academic.oup.com/cercorcomms/article-pdf/2/2/tgab021/38844975/tgab021.pdf |
| File Format | |
| e-ISSN | 26327376 |
| DOI | 10.1093/texcom/tgab021 |
| Journal | Cerebral Cortex Communications |
| Issue Number | 2 |
| Volume Number | 2 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2021-04-01 |
| Access Restriction | Open |
| Subject Keyword | Clinical Neuroscience Medicine and Health Neurology Neuroscience Science and Mathematics Eye Movement Desensitization and Reprocessing (emdr) Functional Magnetic Resonance Imaging (fmri) Hippocampus Post-traumatic Stress Disorder (ptsd) Script-driven Imagery Task |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health Informatics |
