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EPID-08. FINDING THE NEEDLE IN THE HAY STACK – POPULATION-BASED STUDY OF PREDIAGNOSTIC SYMPTOMATIC INTERVAL IN CHILDREN WITH CNS TUMORS
| Content Provider | Oxford Academic |
|---|---|
| Author | Lambert, Clare Goldman, Ran Cochrane, Douglas Dahiya, Anita Mah, Heidi Buttar, Arsh Cheng, Sylvia |
| Copyright Year | 2020 |
| Abstract | Purpose : Delay in diagnosis of central nervous system (CNS) tumors in children is well documented. The aims of this study were to characterize the symptomatology of CNS tumors and the time to diagnosis in a large pediatric hospital in Canada.METHODSRetrospective chart review of children diagnosed with a CNS tumor between 2000 and 2016 in Vancouver, British Columbia, Canada was performed. Data collected included demographics, symptomatology, tumor type, age at diagnosis, known visits to healthcare professionals, neuroimaging, therapy and post treatment relapse or progression.RESULTS148 children with complete medical records were reviewed. The average age at diagnosis was 87.8 months (standard deviation (SD) = 59.7; median = 72). 50.7% of patients had posterior fossa tumors and 49.3% had supratentorial tumors. 30% of patients were diagnosed after a single visit to a health care provider. 7.7% of children needed more than 4 visits. Median total time to diagnosis (PSI) was 62 days (range = 0-2047 days). The longest prediagnostic interval was first symptom onset to first healthcare provider visit (PSI1, median 37 days). Patients with posterior fossa tumors, presence of metastases, and symptoms of ataxia and paresis were associated with shorter PSI.CONCLUSIONSCNS tumors in children continue to pose a diagnostic challenge with significant variability in time to diagnosis. Our population-based study found that median time from symptoms to seeking medical advice by parents was over a month. It is essential to uncover the reasons for delay and address them where possible. |
| Related Links | https://academic.oup.com/neuro-oncology/article-pdf/22/Supplement_3/iii320/34686912/noaa222.194.pdf |
| Ending Page | iii320 |
| Starting Page | iii320 |
| File Format | |
| ISSN | 15228517 |
| e-ISSN | 15235866 |
| DOI | 10.1093/neuonc/noaa222.194 |
| Journal | Neuro-Oncology |
| Issue Number | Suppl_3 |
| Volume Number | 22 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2020-12-04 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Medical Oncology Medicine and Health Neurology Central Nervous System Neoplasms Child Needles Geographic Population Diagnosis Neoplasms Canada Health Personnel Infratentorial Neoplasms Supratentorial Neoplasms Neoplasm Metastasis Parent Paresis Pediatrics Demography British Columbia Neuroimaging Medical Records Ataxia Central Nervous System Medical Records Review Delayed Diagnosis Symptom Onset |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Cancer Research Oncology |
